Lucia Notterpek Selected Research

Myelin Proteins

12/2019	Downregulation of the human peripheral myelin protein 22 gene by miR-29a in cellular models of Charcot-Marie-Tooth disease.
1/2018	Elevated Peripheral Myelin Protein 22, Reduced Mitotic Potential, and Proteasome Impairment in Dermal Fibroblasts from Charcot-Marie-Tooth Disease Type 1A Patients.
1/2015	Inducible HSP70 is critical in preventing the aggregation and enhancing the processing of PMP22.
11/2014	PMP22 is critical for actin-mediated cellular functions and for establishing lipid rafts.
12/2013	Biochemical characterization of protein quality control mechanisms during disease progression in the C22 mouse model of CMT1A.
10/2013	Long-term analyses of innervation and neuromuscular integrity in the Trembler-J mouse model of Charcot-Marie-Tooth disease.
2/2011	Autophagy aids membrane expansion by neuropathic Schwann cells.
8/2010	Rapamycin activates autophagy and improves myelination in explant cultures from neuropathic mice.
4/2009	Intermittent fasting alleviates the neuropathic phenotype in a mouse model of Charcot-Marie-Tooth disease.
10/2008	Pharmacological induction of the heat shock response improves myelination in a neuropathic model.

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Lucia Notterpek Research Topics

Disease

10	Peripheral Nervous System Diseases (PNS Diseases) 01/2015 - 07/2002
8	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) 12/2019 - 03/2005
2	Proteostasis Deficiencies 01/2015 - 07/2014
2	Tomaculous neuropathy 11/2014 - 01/2006
2	Wounds and Injuries (Trauma) 11/2014 - 07/2011
2	Neurodegenerative Diseases (Neurodegenerative Disease) 02/2011 - 02/2002
1	Body Weight (Weight, Body) 01/2019
1	Distal Myopathies (Distal Muscular Dystrophy) 11/2016
1	Glycogen Storage Disease Type II (Pompe's Disease) 02/2015
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 07/2014
1	Synucleinopathies 07/2014
1	Scrapie 07/2014
1	Parkinson Disease (Parkinson's Disease) 07/2014
1	Disease Progression 12/2013
1	Muscular Atrophy (Muscle Atrophy) 10/2013
1	Retinal Detachment (Retinal Detachments) 07/2011
1	Proliferative Vitreoretinopathy 07/2011
1	Schizophrenia (Dementia Praecox) 12/2010
1	Demyelinating Diseases (Demyelinating Disease) 04/2009
1	Porphyrias (Porphyria) 09/2008
1	Tyrosinemias (Tyrosinemia) 09/2008
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2007
1	Carcinoma (Carcinomatosis) 01/2006
1	Traumatic Brain Injuries (Traumatic Brain Injury) 02/2002

Drug/Important Bio-Agent (IBA)

16	Myelin ProteinsIBA 12/2019 - 07/2002
5	Proteins (Proteins, Gene)FDA Link 07/2014 - 12/2010
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2018 - 01/2015
2	Biological ProductsIBA 01/2013 - 05/2003
2	Investigational DrugsIBA 09/2008 - 01/2007
1	Pharmaceutical PreparationsIBA 01/2019
1	Nuclear Matrix-Associated ProteinsIBA 11/2016
1	AcidsIBA 02/2015
1	alpha-Glucosidases (Acid Maltase)IBA 02/2015
1	GlycogenIBA 02/2015
1	SynucleinsIBA 07/2014
1	Biomarkers (Surrogate Marker)IBA 12/2013
1	Indicators and Reagents (Reagents)IBA 01/2013
1	CollagenIBA 07/2011
1	IntegrinsIBA 07/2011
1	Protein AggregatesIBA 02/2011
1	Sirolimus (Rapamycin)FDA Link 02/2011
1	Messenger RNA (mRNA)IBA 12/2010
1	Heme (Haem)IBA 09/2008
1	Aminolevulinic Acid (Levulan)FDA Link 09/2008
1	Glycoproteins (Glycoprotein)IBA 02/2007
1	Integrin beta4IBA 01/2006
1	EpitopesIBA 01/2006
1	beta-Galactosidase (Lactaid)IBA 01/2006
1	UbiquitinIBA 03/2005
1	Membrane Proteins (Integral Membrane Proteins)IBA 07/2004
1	Protein Glutamine gamma Glutamyltransferase 2IBA 02/2002

Therapy/Procedure

3	Therapeutics 07/2014 - 02/2011